Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells
نویسندگان
چکیده
منابع مشابه
Sex Hormones Regulate Tenofovir-Diphosphate in Female Reproductive Tract Cells in Culture
The conflicting results of recent pre-exposure prophylaxis (PrEP) trials utilizing tenofovir (TFV) to prevent HIV infection in women led us to evaluate the accumulation of intracellular TFV-diphosphate (TFV-DP) in cells from the female reproductive tract (FRT) and whether sex hormones influence the presence of TFV-DP in these cells. Following incubation with TFV, isolated epithelial cells, fibr...
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Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV-target cell recruitment. Here we determined whether Tenofovir (TFV), used vaginally in HIV prevention trials, and Tenofovir alafenamide (TAF), an improved prodrug of TFV, interfere with wound healing in the human FRT. TFV ...
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In this paper we consider a fractional order model of HIV infection of CD4+T cells and we transform this fractional order system of ordinary differential equations to a system of weakly singular integral equations. Afterwards we propose a Nystrom method for solving resulting system, convergence result and order of convergence is obtained by using conditions of existence and uniqueness of solut...
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Tenofovir alafenamide (TAF) is a phosphonoamidate prodrug of the nucleotide HIV reverse transcriptase inhibitor tenofovir (TFV). TAF is approved for the treatment of HIV-1 infection as part of the single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and TAF. When dosed once-daily, TAF results in approximately 90% lower levels of plasma TFV and a 4-fold increase in intracell...
متن کاملNumerical analysis of fractional order model of HIV-1 infection of CD4+ T-cells
In this article, we present a fractional order HIV-1 infection model of CD4+ T-cell. We analyze the effect of the changing the average number of the viral particle N with initial conditions of the presented model. The Laplace Adomian decomposition method is applying to check the analytical solution of the problem. We obtain the solutions of the fractional order HIV-1 model in the form of infini...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18078-3